van Meijgaarden, KE and Li, W and Moorlag, SJCFM and Koeken, VACM and Koenen, HJPM and Joosten, LAB and Vyakarnam, A and Ahmed, A and Rakshit, S and Adiga, V and Ottenhoff, THM and Li, Y and Netea, MG and Joosten, SA (2024) BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination. In: Nature Communications, 15 (1).
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Abstract
Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing mycobacterial growth control, here we first investigate the effects of BCG-vaccination in healthy Dutch adults. About a quarter of individuals already control BCG-growth prior to vaccination, whereas a quarter of the vaccinees acquires the capacity to control BCG upon vaccination. This leaves half of the population incapable to control BCG-growth. Single cell RNA sequencing identifies multiple processes associated with mycobacterial growth control. These data suggest (i) that already controllers employ different mechanisms to control BCG-growth than acquired controllers, and (ii) that half of the individuals fail to develop measurable growth control irrespective of BCG-vaccination. These results shed important new light on the variable immune responses to mycobacteria in humans and may impact on improved vaccination against tuberculosis and other diseases. © 2024, The Author(s).
| Item Type: | Journal Article |
|---|---|
| Publication: | Nature Communications |
| Publisher: | Nature Research |
| Additional Information: | The copyright for this article belongs to author |
| Keywords: | bacterium; cell; induced response; RNA; tuberculosis; vaccination, BCG vaccine, adult; child; human; infant; microbiology; Mycobacterium; preschool child; procedures; tuberculosis; vaccination, Adult; BCG Vaccine; Child; Child, Preschool; Humans; Infant; Mycobacterium; Tuberculosis; Vaccination |
| Department/Centre: | Others |
| Date Deposited: | 01 Mar 2024 06:08 |
| Last Modified: | 01 Mar 2024 06:08 |
| URI: | https://eprints.iisc.ac.in/id/eprint/83866 |
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