Photochemotherapeutic Properties of Cu(II) Complexes of L-Lysine and L-Arginine Appended to Anthracene

Banaspati, A and Raza, MK and Goswami, TK (2023) Photochemotherapeutic Properties of Cu(II) Complexes of L-Lysine and L-Arginine Appended to Anthracene. In: ChemistrySelect, 8 (44).

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Abstract

Cu(II) complexes of positively charged amino acids Lâ��Lysine and L-Arginine appended to an anthracene unit and phenanthroline bases, namely Cu(Anth-Lys)(L)(ClO4) (1, 2) and Cu(Anth-Arg)(L)(ClO4) (3, 4) where L is 1,10-phenanthroline (phen, 1 and 3), dipyrido3,2-a : 2â�²,3â�²-cphenazine (dppz, 2 and 4) were synthesized and fully characterized by various spectral and analytical methods. Cu(II) centered broad and weak d-d band in the visible region along with phenanthroline based Ï�â��Ï�* and nâ��Ï�* bands in the UV region were observed in the electronic spectra of the complexes recorded in DMF-Tris-HCl buffer (1 : 4 v/v) (pH 7.2). The complexes 1â��4 show efficient DNA binding propensity. They also demonstrated strong binding affinity for human serum albumin (HSA). The complexes showed efficient visible light-induced cytotoxicity against A549 (human lung carcinoma), HaCaT (human epidermal keratinocytes) and MDA-MB-231(human breast cancer cells) cells with low dark toxicity. They generate both singlet oxygen (1O2) and hydroxyl radical (â� OH) as reactive oxygen species (ROS) upon excitation with visible light which is believed to be responsible for killing cancer cells. Significant changes in the nuclear morphology of the HaCaT cells were observed when treated with complexes 2 and 4 in visible light compared to the non-irradiated cells. © 2023 Wiley-VCH GmbH.

Item Type:	Journal Article
Publication:	ChemistrySelect
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to publisher.
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	29 Feb 2024 06:06
Last Modified:	29 Feb 2024 06:06
URI:	https://eprints.iisc.ac.in/id/eprint/83736

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