Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes

Thakur, M and Muniyappa, K (2023) Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes. In: Journal of Biosciences, 48 (4).

PDF jou_bio__48_2023.pdf - Published Version Restricted to Registered users only Download (440kB)

Abstract

In all cells�from bacteria to humans�nucleotide excision repair (NER) is a highly conserved, versatile DNA repair pathway that is responsible for the removal of a wide variety of DNA helix-distorting lesions arising from both endogenous and exogenous sources. In many organisms including bacteria, fungi, animals, and plants, NER occurs through two sub-pathways: the global genome NER (GG-NER) pathway and the transcription-coupled NER (TC-NER) pathway. Although essential factors and basic steps involved in NER have been identified, mechanisms and stages of their assembly process are not well understood. In this review, we summarize recent literature about protein interaction networks that manifest during initial stages of bacterial NER pathway while highlighting some of the key functional studies. © 2023, Indian Academy of Sciences.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Springer
Additional Information:	The copyright for this article belongs to Springer Publications.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	28 Feb 2024 11:59
Last Modified:	28 Feb 2024 11:59
URI:	https://eprints.iisc.ac.in/id/eprint/83724

Actions (login required)

View Item