A Gallium arsenide composite semi-conductive material-based 2D photonic crystal biosensor for cancer cell detection

Nagarathnegowda, M and Raga, S and Gowre, SK and Miyan, H and Talabattula, S (2023) A Gallium arsenide composite semi-conductive material-based 2D photonic crystal biosensor for cancer cell detection. In: Optical and Quantum Electronics, 55 (12).

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Abstract

In this study, a photonic crystal lattice structure consisting of a Gallium Arsenide composite semi-conductive material with an air background is employed to identify the presence of cancer in red blood cells (RBCs). The five types of cancer being analyzed are breast, basal, cervical, blood, and adrenal gland cancer. The proposed structure's optical and dispersion characteristics are investigated using plane wave expansion and finite difference time domain methods. The proposed structure distinguishes between healthy RBCs and cancer-infected cells by varying the refractive index. The proposed biosensor has a high sensitivity of 1013.2 nm/RIU, a Q-factor of 11,909.199, a low detection limit of 1.647 × 10–4 RIU, a high FOM of 6068.416 RIU−1, an amplitude sensitivity of 9.343 a.u./RIU, and a compact area of 51.66 µm2. Using the proposed structure, it is possible to create a label-free biosensing environment. This device is beneficial in biological applications, such as early cancer diagnosis. As a consequence, overall healthcare system quality has improved. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Item Type:	Journal Article
Publication:	Optical and Quantum Electronics
Publisher:	Springer
Additional Information:	The copyright for this article belongs to by Springer.
Keywords:	Biosensors; Blood; Cells; Conductive materials; Crystal structure; Diseases; Finite difference time domain method; Gallium; Gallium arsenide; III-V semiconductors; Q factor measurement; Refractive index, 2-D photonic crystals; Bio-samples; Cancer; Cancer cell detection; Crystal lattice structure; Material-based; Photonic crystal biosensors; Quality factors; Red blood cell; Sensitivity, Photonic crystals
Department/Centre:	Division of Electrical Sciences > Electrical Communication Engineering
Date Deposited:	14 Dec 2023 03:53
Last Modified:	14 Dec 2023 03:53
URI:	https://eprints.iisc.ac.in/id/eprint/83382

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