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Curcumin-Laden Crosslinked Chitosan–PVA Films: The Synergistic Impact of Genipin and Curcumin on Accelerating Wound Closure

Ramdani, R and Rao, AM and Pokharel, M and Mateti, T and Likhith, K and Kumari, M and Bhatt, SS and Nune, M and Thakur, G (2023) Curcumin-Laden Crosslinked Chitosan–PVA Films: The Synergistic Impact of Genipin and Curcumin on Accelerating Wound Closure. In: JOM .

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Wound dressings play a critical role in healing by maintaining a moist environment and protecting against infection. Here, we fabricate crosslinked films of chitosan–polyvinyl alcohol–genipin–curcumin to investigate the synergistic wound-healing effect of genipin and curcumin. The chemical bonding, morphology, strength, water retention capacity, curcumin release characteristics, and cytotoxicity of the films were investigated. The results showed a 192% increase in tensile strength and good water retention, and the infrared analysis and scanning electron microscopy micrographs confirmed genipin crosslinking and the presence of curcumin in the films, whose morphology was uniform and continuous. The curcumin-loaded films were found to have insignificant cytotoxicity against 3T3 fibroblast cells, proving their biocompatibility. The curcumin dissolution tests determined the amount of curcumin released from the films with time, and assessed the release characteristics to be sustained at all pH levels. In vivo trials were carried out on rodents to evaluate the wound-healing effects of the films, and the results showed that the curcumin-incorporated crosslinked films accelerated wound healing compared to the uncrosslinked and curcumin-absent films, confirming their effectiveness for wound healing. © 2023, The Author(s).

Item Type: Journal Article
Publication: JOM
Publisher: Springer
Additional Information: The copyright for this article belongs to the Authors.
Keywords: Biocompatibility; Cell culture; Chemical bonds; Chitosan; Crosslinking; Mammals; Scanning electron microscopy; Tensile strength, Cross linked chitosan; Cross-linked films; Curcumin; Genipin; PVA films; Release characteristics; Wound closure; Wound dressings; Wound healing; Wound healing effects, Morphology
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Date Deposited: 28 Nov 2023 09:43
Last Modified: 28 Nov 2023 09:43
URI: https://eprints.iisc.ac.in/id/eprint/83271

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