Viral nanoparticles: Current advances in design and development

Arul, SS and Balakrishnan, B and Handanahal, SS and Venkataraman, S (2023) Viral nanoparticles: Current advances in design and development. In: Biochimie .

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Abstract

Viral nanoparticles (VNPs) are self-assembling, adaptable delivery systems for vaccines and other therapeutic agents used in a variety of biomedical applications. The potential of viruses to invade and infect various hosts and cells renders them suitable as potential nanocarriers, possessing distinct functional characteristics, immunogenic properties, and improved biocompatibility and biodegradability. VPNs are frequently produced through precise genetic or chemical engineering, which involves adding diverse sequences or functional payloads to the capsid protein (CP). Several spherical and helical plant viruses, bacteriophages, and animal viruses are currently being used as VNPs, or non-infectious virus-like particles (VLPs). In addition to their broad use in cancer therapy, vaccine technology, diagnostics, and molecular imaging, VNPs have made important strides in the realms of tissue engineering, biosensing, and antimicrobial prophylaxis. They are also being used in energy storage cells due to their binding and piezoelectric properties. The large-scale production of VNPs for research, preclinical testing, and clinical use is fraught with difficulties, such as those relating to cost-effectiveness, scalability, and purity. Consequently, many plants- and microorganism-based platforms are being developed, and newer viruses are being explored. The goal of the current review is to provide an overview of these advances. © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)

Item Type:	Journal Article
Publication:	Biochimie
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to the Elsevier B.V.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	05 Nov 2023 05:39
Last Modified:	05 Nov 2023 05:39
URI:	https://eprints.iisc.ac.in/id/eprint/83099

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