Copper Metallogel as Potential Drug Carrier for Anti-Inflammatory Drugs

Choudhary, P and Gaur, R and Rambabu, D and Dhir, A and Gupta, A and Pooja, P (2021) Copper Metallogel as Potential Drug Carrier for Anti-Inflammatory Drugs. In: ChemistrySelect, 6 (34). pp. 9139-9143.

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Abstract

Copper based Metal-Organic Gels (MOGs) were evaluated for their efficiency as drug carrier for four anti-inflammatory drugs viz. 5-Fluorouracil (5FU), Phenidone (PN), Ibuprofen (IBP) and Cisplatin (CP). Copper(II)-benzene tricarboxylic acid (CuBTC) was used as a precursor for the loading and releasing of these drugs. The distinctive porous nature of the gel provided the high loading efficiency for these anti-inflammatory drugs. Among all the drugs evaluated, CuBTC@5FU exhibited maximum drug loading (88.1 %) and releasing (95 %) efficiency at physiological pH 5.2, which was attributed to the strong hydrogen bonding interactions between CuBTC and fluoride of 5FU.

Item Type:	Journal Article
Publication:	ChemistrySelect
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to the John Wiley and Sons Inc.
Keywords:	Anti-Inflammatory drugs; Drug delivery; Drug loading; Metal-organic frameworks; Metal-organic gels.
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	26 Nov 2023 08:17
Last Modified:	26 Nov 2023 08:17
URI:	https://eprints.iisc.ac.in/id/eprint/82937

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