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Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction

Palmer, ND and Kahali, B and Kuppa, A and Chen, Y and Du, X and Feitosa, MF and Bielak, LF and O'Connell, JR and Musani, SK and Guo, X and Smith, AV and Ryan, KA and Eirksdottir, G and Allison, MA and Bowden, DW and Budoff, MJ and Carr, JJ and Chen, Y-DI and Taylor, KD and Correa, A and Crudup, BF and Halligan, B and Yang, J and Kardia, SLR and Launer, LJ and Fu, Y-P and Mosley, TH and Norris, JM and Terry, JG and O'Donnell, CJ and Rotter, JI and Wagenknecht, LE and Gudnason, V and Province, MA and Peyser, PA and Speliotes, EK (2021) Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction. In: Human Molecular Genetics, 30 (15). pp. 1443-1456.

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Official URL: https://doi.org/10.1093/hmg/ddab096


Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the largest multiethnic investigation of exonic variation associated with NAFLD and correlated metabolic traits and diseases. An exome array meta-analysis was carried out among eight multiethnic population-based cohorts (n=16 492) with computed tomography (CT) measured hepatic steatosis. A fixed effects meta-analysis identified five exome-wide significant loci (P[removed]

Item Type: Journal Article
Publication: Human Molecular Genetics
Publisher: Oxford University Press
Additional Information: The copyright for this article belongs to the Author.
Keywords: alanine aminotransferase; apolipoprotein E; cholesterol; triacylglycerol; alanine aminotransferase; ApoE protein, human; apolipoprotein E; triacylglycerol, adult; African American; alanine aminotransferase blood level; allele; Alzheimer disease; American; ancestry group; Article; Asian American; biobank; cardiovascular risk; computer assisted tomography; controlled study; disease association; ethnicity; European; European American; exome; exon; fatty liver; female; gender; gene; gene locus; genetic association; genetic risk; genetic variation; heart infarction; Hispanic; human; liver cirrhosis; male; metabolic parameters; nonalcoholic fatty liver; obesity; population research; radiation attenuation; risk reduction; tomm40 gene; exome; gene frequency; genetic database; genetics; genome-wide association study; liver; metabolism; nonalcoholic fatty liver; obesity; phenotype; procedures; prognosis; risk factor; single nucleotide polymorphism, Alanine Transaminase; Alleles; Alzheimer Disease; Apolipoproteins E; Databases, Genetic; Exome; Gene Frequency; Genome-Wide Association Study; Humans; Liver; Liver Cirrhosis; Myocardial Infarction; Non-alcoholic Fatty Liver Disease; Obesity; Phenotype; Polymorphism, Single Nucleotide; Prognosis; Risk Factors; Triglycerides
Department/Centre: Autonomous Societies / Centres > Centre for Brain Research
Date Deposited: 17 Aug 2023 08:40
Last Modified: 17 Aug 2023 08:40
URI: https://eprints.iisc.ac.in/id/eprint/82793

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