Highly Accurate Protein Structure Classification and Prediction

Saha, A and Sarkar, I (2023) Highly Accurate Protein Structure Classification and Prediction. In: 2nd International Conference on Computational Systems and Communication, ICCSC 2023, 3- 4 March 2023, Thiruvananthapuram.

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Abstract

Proteins are the main building blocks for any form of life known to us as of now, and it is the actuators of biophysical and chemical events occurring in living organisms. Biological functions are enabled by their naive structure, which plays a very important and crucial role in the design of vaccines and drugs. This acts as one of the main sources of motivation in predicting protein structure from its sequence of amino acids coupled with other information to get highly accurate prediction and classification, which indeed is one of the fundamental computational biology problems. As of now, not much focus has been given to the inclusion of sidechain structure information and prediction of the protein backbone. In this paper, it is shown that a new dataset called SidechainNet, which extends from the ProteinNet dataset, can be used to predict and classify the structure of proteins more accurately. This is because SidechainNet consists of angle and atomic coordinate information, which describes almost all the heavy atoms of each and every protein structure. The background information on the availability of data on the protein structure and the importance of ProteinNet is discussed. It is followed by the beneficial inclusion of additional information that SidechainNet has, which helps in predicting the structure of the protein more accurately. At last, it is shown how using a Machine Learning model, a highly accurate protein structure is obtained by applying SidechainNet as its dataset.

Item Type:	Conference Paper
Publication:	ICCSC 2023 - Proceedings of the 2nd International Conference on Computational Systems and Communication
Publisher:	Institute of Electrical and Electronics Engineers Inc.
Additional Information:	The copyright for this article belongs to the Institute of Electrical and Electronics Engineers Inc.
Keywords:	computational biology; machine learning; protein structure; ProteinNet; SidechainNet
Department/Centre:	Division of Interdisciplinary Sciences > Computational and Data Sciences
Date Deposited:	24 Jul 2023 05:22
Last Modified:	24 Jul 2023 05:22
URI:	https://eprints.iisc.ac.in/id/eprint/82540

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