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Intrinsically disordered proteins and conformational noise: The hypothesis a decade later

Kulkarni, P and Salgia, R and Rangarajan, G (2023) Intrinsically disordered proteins and conformational noise: The hypothesis a decade later. Elsevier Inc..

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Official URL: https://doi.org/10.1016/j.isci.2023.107109


Phenotypic plasticity is the ability of individual genotypes to produce different phenotypes in response to environmental perturbations. We previously postulated how conformational noise emanating from conformational dynamics of intrinsically disordered proteins (IDPs) which is distinct from transcriptional noise, can contribute to phenotypic switching by rewiring the cellular protein interaction network. Since most transcription factors are IDPs, we posited that conformational noise is an integral component of transcriptional noise implying that IDPs may amplify total noise in the system either stochastically or in response to environmental changes. Here, we review progress in elucidating the details of the hypothesis. We highlight empirical evidence supporting the hypothesis, discuss conceptual advances that underscore its fundamental importance and implications, and identify areas for future investigations.

Item Type: Other
Publication: iScience
Publisher: Elsevier Inc.
Additional Information: The copyright for this article belongs to the Author.
Keywords: Biochemistry; Biological sciences; Cell biology; Molecular biology
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Division of Physical & Mathematical Sciences > Mathematics
Date Deposited: 20 Jul 2023 10:57
Last Modified: 20 Jul 2023 10:57
URI: https://eprints.iisc.ac.in/id/eprint/82512

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