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Tools and approaches for assessing stress-responsive secondary metabolites to design climate-smart crops

Das, DR and Sarkar, M and Paul, A (2023) Tools and approaches for assessing stress-responsive secondary metabolites to design climate-smart crops. [Book Chapter]

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Official URL: https://doi.org/10.1201/9781003346173


Agricultural environments are constantly jeopardized by abiotic stresses, including periodical droughts, temperature extremes, water deficit, flooding, salinity, and changes in atmospheric CO2 levels. These agro-climatic factors severely affect crop quality, productivity, and yield. Crop plants' responses to such drastic climatic stresses involve alterations in gene expression and extensive metabolic reprogramming, impacting their proteome and metabolome. Thereby, the plants ensure metabolic homeostasis and improved stress tolerance. Among multiple adaptive responses, the production and accumulation of low molecular weight, chemically diverse, bioactive, exogenous, and endogenous secondary metabolites (SMs) are noteworthy. Metabolites are spatio-temporal chemical footprints of the cellular state under particular physiological or developmental conditions that reflect the complex crosstalk between genotype and the environment. Consequently, it is imperative to conduct a qualitative and quantitative assessment of the multi-parametric metabolic responses, analyze reconfigured metabolic networks under diverse stress conditions, and identify the underlying candidate genes in various metabolic biosynthetic pathways. Herein, we discuss the advances in analytical methods and sequencing technologies which offer high-throughput, cutting-edge, and cost-effective techniques for systematic identification of SMs and genetic dissection of commercially important agronomic traits. Integration of metabolomics with transcriptomics allows large-scale metabolite profiling with desirable accuracy and coverage, and mapping of trait-specific markers with high confidence levels, respectively. Inferring from large volumes of multi-omics data facilitates the identification of metabolic biomarkers and enables informed decision-making for crop breeding programs, which aim to develop climate-smart future crops with enhanced fitness, improved productivity, and increased stress tolerance.

Item Type: Book Chapter
Publication: Biology and Biotechnology of Environmental Stress Tolerance in Plants: Volume 1: Secondary Metabolites in Environmental Stress Tolerance
Publisher: Apple Academic Press
Additional Information: The copyright for this article belongs to the Apple Academic Press.
Keywords: Abiotic stress; Differentially expressed genes; Mass spectrometry; Metabolite fingerprinting; Metabolite profiling; Metabolomics; Nuclear magnetic resonance spectroscopy; RNA sequencing; Secondary metabolites; Transcriptomics.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 24 Jul 2023 05:19
Last Modified: 24 Jul 2023 05:19
URI: https://eprints.iisc.ac.in/id/eprint/82454

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