Flexible Microelectrode Array for Chronic Electrocorticography Recording under Different Neurophysiological Conditions

Chatterjee, S and Joshi, RK and Shabari Girishan, KV and Pandya, HJ (2023) Flexible Microelectrode Array for Chronic Electrocorticography Recording under Different Neurophysiological Conditions. In: 11th International IEEE/EMBS Conference on Neural Engineering, NER 2023, 25 - 27 April 2023, Baltimore.

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Abstract

Electrocorticography signal acquisition using implanted flexible microelectrode arrays is a popular approach for neural status monitoring. This interdisciplinary research shows the design, fabrication, characterization, and validation of a 10-channel flexible microelectrode array for chronic electrocorticography acquisition from a rat. The array was fabricated using titanium/gold electrodes, flexible biocompatible polyimide as substrate as well as insulation layers. The fabricated array facilitated subdural recording from the cortical surface of a rat. The reliability of the developed electrode array, subsequent acquisition module, and preprocessing approach was checked for an epilepsy model in rodents. Peripheral electrical stimulation was used to elicit epilepsy, minimizing tissue damage. The implanted array faithfully recorded baselines, epileptic activities induced by peripheral electrical stimulation at the forepaw, recovered baselines upon antiepileptic drug administration, and the somatosensory evoked potentials by touching whiskers in a chronic study. The preprocessed traces from the awake and sedated rats ensured the utilization potential of this array for chronic signal acquisition. Subsequently, the time-frequency analysis of the extracted signals shows a significant contrast in temporal features among the neurophysiological conditions. The OpenBCI Cyton Boards were used in these studies to acquire brain signals. Histology of the formalin-fixed rat brain showed no significant damage due to implantation.

Item Type:	Conference Paper
Publication:	International IEEE/EMBS Conference on Neural Engineering, NER
Publisher:	IEEE Computer Society
Additional Information:	The copyright for this article belongs to the IEEE Computer Society.
Keywords:	antiepileptic drug; electrocorticography signals; flexible microelectrode array; induced epileptic activities; peripheral electrical stimulation
Department/Centre:	Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology)
Date Deposited:	13 Jul 2023 09:45
Last Modified:	13 Jul 2023 09:45
URI:	https://eprints.iisc.ac.in/id/eprint/82420

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