Patel, J and Tripathi, E (2023) Targeting the Ubiquitin Machinery for Cancer Therapeutics. [Book Chapter]
Full text not available from this repository.Abstract
The ubiquitin–proteasome system (UPS) is an important player in various biological processes maintaining cellular homeostasis. The regulation of all essential components of UPS (Ubiquitinating enzymes-E1, E2, E3, deubiquitinases, and proteasome machinery) is complex and multifaceted, and their dysregulation has been implicated in several diseases including cancer. Increasing number of studies has established UPS as a cancer therapeutic target. In this chapter, we discuss the role of each component of the ubiquitin pathway in maintaining physiological function and their deregulation in cancer. In addition, we also discuss the enzymes that could serve as promising drug targets for anticancer therapy.
| Item Type: | Book Chapter |
|---|---|
| Publication: | Drug Repurposing for Emerging Infectious Diseases and Cancer |
| Publisher: | Springer Nature |
| Additional Information: | The copyright for this article belongs to Springer Nature |
| Keywords: | Cancer therapy; Deubiquitination; Proteasome; Ubiquitination |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 07 Jul 2023 16:14 |
| Last Modified: | 07 Jul 2023 16:14 |
| URI: | https://eprints.iisc.ac.in/id/eprint/82101 |
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