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Targeting the Ubiquitin Machinery for Cancer Therapeutics

Patel, J and Tripathi, E (2023) Targeting the Ubiquitin Machinery for Cancer Therapeutics. [Book Chapter]

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Official URL: https://doi.org/10.1007/978-981-19-5399-6_9


The ubiquitin–proteasome system (UPS) is an important player in various biological processes maintaining cellular homeostasis. The regulation of all essential components of UPS (Ubiquitinating enzymes-E1, E2, E3, deubiquitinases, and proteasome machinery) is complex and multifaceted, and their dysregulation has been implicated in several diseases including cancer. Increasing number of studies has established UPS as a cancer therapeutic target. In this chapter, we discuss the role of each component of the ubiquitin pathway in maintaining physiological function and their deregulation in cancer. In addition, we also discuss the enzymes that could serve as promising drug targets for anticancer therapy.

Item Type: Book Chapter
Publication: Drug Repurposing for Emerging Infectious Diseases and Cancer
Publisher: Springer Nature
Additional Information: The copyright for this article belongs to Springer Nature
Keywords: Cancer therapy; Deubiquitination; Proteasome; Ubiquitination
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 07 Jul 2023 16:14
Last Modified: 07 Jul 2023 16:14
URI: https://eprints.iisc.ac.in/id/eprint/82101

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