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Nonhomologous DNA End Joining in Mammalian Cells

Ray, U and Raghavan, SC (2022) Nonhomologous DNA End Joining in Mammalian Cells. [Book Chapter]

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Official URL: https://doi.org/10.1016/B978-0-12-821618-7.00101-2


DNA double-strand breaks (DSBs) are considered as the most lethal types of lesions to DNA. Organisms have evolved with three major types of DSB repair, namely homologous recombination, nonhomologous end joining and alternative or microhomology mediated end joining. Among these, NHEJ is believed to repair majority of DSBs generated in a mammalian cell. Although initially evolved as a two-component system consisting of KU and Ligase, NHEJ involves concerted action of multiple proteins including accessory factors which enable efficient repair at the broken DNA ends. This article explores the role of core and accessory factors of NHEJ, choice of repair pathway, associated end chemistry and small molecule inhibitors thereof.

Item Type: Book Chapter
Publication: Encyclopedia of Cell Biology: Volume 1-6, Second Edition
Publisher: Elsevier
Additional Information: The copyright for this article belongs to Elsevier.
Keywords: Alternative NHEJ (A-NHEJ); Cancer therapy; DNA double-strand break (DSB); DNA end chemistry; DSB Repair; Genome stability; Genomic instability; Homologous recombination; Microhomology mediated end joining (MMEJ); NHEJ and associated diseases; Nonhomologous DNA end joining (NHEJ); Small molecule inhibitors
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 15 Jun 2023 09:23
Last Modified: 15 Jun 2023 09:23
URI: https://eprints.iisc.ac.in/id/eprint/82010

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