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Cellular and Organismal Responses to Infections in Caenorhabditis elegans

Filipowicz, A and Aballay, A and Singh, V (2022) Cellular and Organismal Responses to Infections in Caenorhabditis elegans. [Book Chapter]

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Official URL: https://doi.org/10.1016/B978-0-12-821618-7.00043-2


The nematode Caenorhabditis elegans has emerged as a powerful model system to study cellular responses to microbial infections in the context of a whole animal. Like other free-living nematodes, the one-millimeter-long nematode C. elegans lives in the soil and on rotting fruit, where it is in contact with several microbes, including human microbial pathogens. While it lacks an adaptive immune system and professional phagocytes involved in defense against pathogens, it possesses mechanisms to recognize different microbes and to respond accordingly. C. elegans does not seem to have conserved pattern recognition receptors (PRRs) for pathogen detection through known microbe-associated molecular patterns (MAMPs). Still, it can recognize pathogen attacks through different mechanisms, including the neuronal sensation of bacterial cues and detection of disturbances of cellular homeostasis. The immune response mounted by C. elegans upon pathogen infection comprises evolutionarily conserved signaling pathways that result in avoidance of pathogens and the induction of immune effector mechanisms to combat infections. © 2023 Elsevier Inc. All rights reserved.

Item Type: Book Chapter
Publication: Encyclopedia of Cell Biology: Volume 1-6, Second Edition
Publisher: Elsevier
Additional Information: The copyright for this article belongs to Elsevier.
Keywords: Behavioral immunity; Caenorhabditis elegans; Cellular homeostasis; Cellular response to infection; Effector-triggered immunity; ER-stress; Host-pathogen interactions; Immune effectors; Innate immunity; Microbial pathogens; Neuroimmune interactions; Pathogen avoidance; Unfolded protein response
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 14 Jun 2023 11:12
Last Modified: 14 Jun 2023 11:12
URI: https://eprints.iisc.ac.in/id/eprint/82006

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