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Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next-Generation Therapeutics

Singh, N and Sherin, GR and Mugesh, G (2023) Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next-Generation Therapeutics. In: Angewandte Chemie - International Edition .

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Official URL: https://doi.org/10.1002/anie.202301232


Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability to replace natural enzymes in various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating the cellular redox status by mimicking the antioxidant enzymes in mammalian cells are of great therapeutic significance in oxidative-stress-mediated disorders. As the distinction of physiological oxidative stress (oxidative eustress) and pathological oxidative stress (oxidative distress) occurs at a fine borderline, it is a great challenge to design nanozymes that can differentially sense the two extremes in cells, tissues and organs and mediate appropriate redox chemical reactions. In this Review, we summarize the advances in the development of redox-active nanozymes and their biomedical applications. We primarily highlight the therapeutic significance of the antioxidant and prooxidant nanozymes in various disease model systems, such as cancer, neurodegeneration, and cardiovascular diseases. The future perspectives of this emerging area of research and the challenges associated with the biomedical applications of nanozymes are described.

Item Type: Journal Article
Publication: Angewandte Chemie - International Edition
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to John Wiley and Sons Inc.
Keywords: Bioimaging; Drug delivery; Enzyme activity; Mammals; Medical applications; Neurodegenerative diseases; Oxidative stress; Redox reactions; Superoxide dismutase, Biomedical applications; Biosensing; Catalase; Cellular redox regulation; Glutathione peroxidase; Nanozyme; Natural enzyme; Pro-oxidants; Super oxide dismutase; Superoxide dismutases, Antioxidants
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 15 Jun 2023 08:27
Last Modified: 15 Jun 2023 08:27
URI: https://eprints.iisc.ac.in/id/eprint/81983

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