Heavy metal–induced genotoxic, physiological, and biochemical responses in Schizothorax esocinus (Heckel 1838) inhabiting the Dal Lake, India, and phytoremediation by indwelling plants

Banday, UZ and Nazir, A and Fatima, M and Swaleh, SB and Al-asadi, M and Usmani, N (2023) Heavy metal–induced genotoxic, physiological, and biochemical responses in Schizothorax esocinus (Heckel 1838) inhabiting the Dal Lake, India, and phytoremediation by indwelling plants. In: Environmental Science and Pollution Research, 30 (24). pp. 65688-65701.

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Abstract

Heavy metals have an immense impact on aquatic ecosystems, and their toxic effects are transferred to the inhabiting organisms. Experiments were conducted to investigate the health of snow trout Schizothorax esocinus inhabiting Dal Lake. Heavy metals (Cd > Ni > Cu > Cr) were found to accumulate in the major immune organs of the fish (head kidney, liver, spleen, thymus) which led to change in the overall physiology. The head kidney, liver, and spleen of a fish contain high amount of these metals. The least accumulation of these metals was found in the blood, whereas Cd and Ni were completely absent in the integument. Hepatic marker enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)) were normal, while the renal marker enzyme creatine kinase showed marked difference in its value. The cortisol level was normal, while immunoglobulin M showed elevated level representing active immunity. At a cellular level, the histopathology of immune organs showed marked damage. Metallothionein (MT) and glutathione peroxidase (GPX) genes showed variable expression pattern in the immune organs with the head kidney showing the highest expression of both the genes, and blood showed the least. We observed that the aquatic plants (Nelumbo nucifera and Trapa natans) inhabiting the lake played an important role in phytoremediation. An integrated approach involving biochemical, hematological, genotoxic, and histopathological studies can provide a valuable information to understand fish adaptive patterns and monitor water quality. Graphical Abstract: Figure not available: see fulltext.. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Item Type:	Journal Article
Publication:	Environmental Science and Pollution Research
Publisher:	Springer Science and Business Media Deutschland GmbH
Additional Information:	The copyright of this article belongs to the Authors.
Keywords:	Enzymes; Genotoxicity; Heavy metals; Immunity; Schizothorax esocinus
Department/Centre:	Division of Interdisciplinary Sciences > Interdisciplinary Centre for Water Research
Date Deposited:	14 Jun 2023 08:57
Last Modified:	14 Jun 2023 08:57
URI:	https://eprints.iisc.ac.in/id/eprint/81871

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