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Biomaterial strategies to combat implant infections: new perspectives to old challenges

Braem, A and Kamarudin, NHN and Bhaskar, N and Hadzhieva, Z and Mele, A and Soulié, J and Linklater, DP and Bonilla-Gameros, L and Boccaccini, AR and Roy, I and Drouet, C and Ivanova, EP and Mantovani, D and Basu, B (2023) Biomaterial strategies to combat implant infections: new perspectives to old challenges. In: International Materials Reviews .

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Official URL: https://doi.org/10.1080/09506608.2023.2193784


Peri-implant infection is rapidly becoming an–if not the most–important clinical challenge for indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of such infections, a plethora of biomaterials/bioengineering-based antimicrobial strategies are emerging to restrict or ideally to eliminate microbial adhesion and biofilm formation on implant surfaces. Yet, the development of such approaches faces specific challenges, like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues and antibiotic resistance development, which limit translation to the clinic. This review provides insights into the antimicrobial activity of current state-of-the-art biomaterial-based approaches to address the aforementioned issues. Translational research strategies and regulatory framework are also emphasised as key elements facilitating clinical implementation of anti-infective biomaterials. This review closes with the vision that the integration of computational tools and experimental databases using artificial intelligence (AI) would provide new insights for the accelerated development of next-generation biomaterial-based antimicrobial strategies. © 2023 Institute of Materials, Minerals and Mining and ASM International Published by Taylor & Francis on behalf of the Institute and ASM International.

Item Type: Journal Article
Publication: International Materials Reviews
Publisher: Taylor and Francis Ltd.
Additional Information: The copyright of this article belongs to Taylor and Francis Ltd.
Keywords: Antibiotics; Biocompatibility; Cell adhesion; Clinical research; Microorganisms; Adhesion formations; Antimicrobial therapy; Implant infections; Implantable medical devices; Medical Devices; Microbial adhesion; Microbial biofilm; Peri-implant infections; Smart multifunctional biomaterial; Surface-modification; Biofilms
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Date Deposited: 14 Jun 2023 08:30
Last Modified: 14 Jun 2023 08:30
URI: https://eprints.iisc.ac.in/id/eprint/81869

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