Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity

Das, D and Noor, A and Raza, MK and Goswami, TK (2021) Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity. In: Journal of Biological Inorganic Chemistry, 26 (8). pp. 895-896.

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Abstract

Co(II) complexes having a ferrocene-based curcuminoid (Fc-curH) ligand viz. [Co(L)2(Fc-cur)]ClO4 (1, 2), where L is phenanthroline base, namely, 1,10-phenanthroline (phen in 1) and dipyrido[3,2-a:2’,3’-c]phenazine (dppz in 2) have been synthesized, characterized and evaluated as photochemotherapeutic agents in vitro. The corresponding Co(II) complexes of the naturally occurring polyphenol curcumin (curH), namely, [Co(L)2(cur)]ClO4 (3, 4), where L is phen (in 3) and dppz (in 4) were synthesized and their photo-induced anticancer activities compared with their ferrocene containing counterparts 1 and 2. The Co(II) acetylacetonato complex viz. [Co(phen)2(acac)]ClO4 (5) was structurally characterized through X-ray crystallography and used as control for cellular experiments. The Co(II) complexes having ferrocene-based curcuminoid are remarkably stable at physiological condition with higher lipophilicity compared to their curcumin analogues. The complexes display significant binding propensity to calf thymus (ct) DNA and human serum albumin (HSA). The complexes 1–4 display remarkable visible light induced cytotoxicity with the ferrocenyl analogues showing more phototoxic index (PI). The Co(II) curcumin complexes localize in the nucleus and mitochondria of A549 cells. The primary cell death mechanism is believed to be apoptotic in nature induced by light assisted generation of reactive oxygen species (ROS). Graphic abstract[Figure not available: see fulltext.

Item Type:	Journal Article
Publication:	Journal of Biological Inorganic Chemistry
Publisher:	Springer Science and Business Media Deutschland GmbH
Additional Information:	The copyright for this article belongs to Springer Science and Business Media Deutschland GmbH
Keywords:	Co(II) complexes · Crystal structure · Curcumin · Ferrocene-based curcuminoid · Photo-induced cytotoxicity · ROS generation · Apoptosis
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry Division of Physical & Mathematical Sciences > Physics
Date Deposited:	09 Jun 2023 11:00
Last Modified:	09 Jun 2023 11:00
URI:	https://eprints.iisc.ac.in/id/eprint/81838

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