Bacterial Multidrug Tolerance and Persisters: Understanding the Mechanisms, Clinical Implications, and Treatment Strategies

Singla, M and Chaudhary, V and Ghosh, A (2022) Bacterial Multidrug Tolerance and Persisters: Understanding the Mechanisms, Clinical Implications, and Treatment Strategies. [Book Chapter]

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Abstract

Antibiotic resistance is a massive problem in today’s world and a serious threat to human civilization. Apart from being genetically resistant to antibiotics, the other important mechanism by which pathogenic bacteria can evade antibiotics is multidrug tolerance through the formation of persisters. In contrast to antibiotic-resistant bacteria, persister cells require no heritable genetic changes for surviving antibiotic treatment but become drug tolerant due to transient growth arrest. Since most antibiotics only target active metabolic pathways in the growing cells, non-growing persisters can escape the bactericidal effects of antibiotics and resume growth once the antibiotic is withdrawn resulting in treatment failure. Here in this book chapter, we try to highlight different aspects of persisters starting from unique characteristics of persisters, mechanisms of persister formation, clinical relevance, different techniques to study persisters, and some promising treatment options. Finally, we emphasize how focused research in this particular field can have a big impact to eradicate antimicrobial resistance. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.

Item Type:	Book Chapter
Publication:	Antimicrobial Resistance: Underlying Mechanisms and Therapeutic Approaches
Publisher:	wiley
Additional Information:	The copyright for this article belongs to wiley.
Keywords:	Antibiotic tolerance; Biofilm; Dormancy; Persisters; Quorum sensing; Resistance; SOS response; Stringent response
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	09 May 2023 03:47
Last Modified:	09 May 2023 03:47
URI:	https://eprints.iisc.ac.in/id/eprint/81626

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