Nagaraj, H and Narayanan, R (2023) Plasticity manifolds and degeneracy govern circadian oscillations of neuronal intrinsic properties in the suprachiasmatic nucleus. In: iScience, 26 (4).
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Abstract
A heterogeneous neuronal population in the suprachiasmatic nucleus (SCN) sustains a cell-autonomous code for circadian time, implemented by firing-rate plasticity involving multiple ion channels. How do SCN neurons undergo stable firing-rate transitions if several ion channels change simultaneously in a heterogeneous neuronal population? Here, we addressed this question by building a heterogeneous population of SCN model neurons, each allowed to undergo one complete circadian cycle through multiple possible routes. We found that SCN neurons could achieve signature electrophysiological characteristics (day-like or night-like) despite pronounced heterogeneity in ion-channel conductances. Furthermore, for any neuron, disparate combinations of ion-channel plasticity yielded valid day-to-night or night-to-day transitions. Finally, nonlinear dimensionality reduction analyses on valid plasticity spaces revealed a low-dimensional plasticity manifold in day-to-night transitions, but not in night-to-day transitions. Our analyses unveil a synthesis of the degeneracy and the plasticity manifold frameworks that provides robustness and flexibility in achieving precise transitions despite widespread heterogeneities.
| Item Type: | Journal Article |
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| Publication: | iScience |
| Publisher: | Elsevier Inc. |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | Neuroscience |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 23 May 2023 03:21 |
| Last Modified: | 23 May 2023 03:21 |
| URI: | https://eprints.iisc.ac.in/id/eprint/81551 |
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