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Zebrafish Model System in Antimicrobial Drug Discovery

Pamanji, R (2020) Zebrafish Model System in Antimicrobial Drug Discovery. [Book Chapter]

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Official URL: https://doi.org/10.1007/978-981-15-1695-5_30


Zebrafish (Danio rerio) has already been used in disease modelling and drug discovery. The development of zebrafish as an infectious disease model for studying human diseases has paved the path in understanding pathogenesis and host-pathogen interactions. Many pathogenic zebrafish models were generated using different species of bacteria, parasites, fungus, and virus which are pathogenic to humans and studied their pathogenesis, but very few people tested the antimicrobial drugs on the diseased models. In the present chapter we have been trying to discuss common diseases of zebrafish along with infectious diseases modelled and the importance of zebrafish in antimicrobial drug discovery, how relevant its immune system with that of humans is in defense against pathogens and drug metabolism. The limitations like how antibiotics are harmful to early stages of development and relevance of using the larval and adult zebrafish were also discussed.

Item Type: Book Chapter
Publication: Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery
Publisher: Springer Singapore
Additional Information: The copyright for this article belongs to Springer Singapore.
Keywords: Antimicrobial; Drug discovery; Infectious diseases; Zebrafish
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 29 May 2023 03:20
Last Modified: 29 May 2023 03:20
URI: https://eprints.iisc.ac.in/id/eprint/81538

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