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Role of lactoyl-glutathione lyase of Salmonella in the colonization of plants under salinity stress

Karmakar, K and Chakraborty, S and Kumar, JR and Nath, U and Nataraja, KN and Chakravortty, D (2023) Role of lactoyl-glutathione lyase of Salmonella in the colonization of plants under salinity stress. In: Research in Microbiology, 174 (4).

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Official URL: https://doi.org/10.1016/j.resmic.2023.104045


Salmonella, a foodborne human pathogen, can colonize the members of the kingdom Plantae. However, the basis of the persistence of Salmonella in plants is largely unknown. Plants encounter various biotic and abiotic stress agents in soil. We conjectured that methylglyoxal (MG), one of the common metabolites that accumulate in plants during both biotic and abiotic stress, plays a role in regulating the plant-Salmonella interaction. The interaction of Salmonella Typhimurium with plants under salinity stress was investigated. It was observed that wild-type Salmonella Typhimurium can efficiently colonize the root, but mutant bacteria lacking MG detoxifying enzyme, lactoyl-glutathione lyase (Lgl), showed lower colonization in roots exclusively under salinity stress. This colonization defect is due to the poor viability of the mutated bacterial strains under these conditions. This is the first report to prove the role of MG-detoxification genes in the colonization of stressed plants and highlights the possible involvement of metabolic genes in the evolution of the plant-associated life of Salmonella. © 2023 Institut Pasteur

Item Type: Journal Article
Publication: Research in Microbiology
Publisher: Elsevier Masson s.r.l.
Additional Information: The copyright for this article belongs to Elsevier Masson s.r.l.
Keywords: Lactoyl-glutathione lyase; Metabolism; Methylglyoxal; Salinity; Salmonella
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 21 Apr 2023 10:23
Last Modified: 21 Apr 2023 10:23
URI: https://eprints.iisc.ac.in/id/eprint/81366

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