Antidiabetic potential of Gymnemic acid mediated gold nanoparticles (Gym@AuNPs) on Streptozotocin-induced diabetic rats-An implication on in vivo approach

Kumar Seetharaman, P and Ramalingam, P and Chandrika, M and Rajan, R and Chelliah, J and bo, L (2023) Antidiabetic potential of Gymnemic acid mediated gold nanoparticles (Gym@AuNPs) on Streptozotocin-induced diabetic rats-An implication on in vivo approach. In: International Journal of Pharmaceutics, 636 .

PDF int_jou_pha_636_2023.pdf - Published Version Restricted to Registered users only Download (9MB) | Request a copy

Abstract

Gymnemic acid is glycosides of triterpene with recognized and valuable applications for several chronic diseases, mainly diabetics. Despite this, it requires a delivery system in order to range its therapeutic target due to its limited solubility and bioavailability. Therefore, the Gymnemic acid mediated gold nanoparticles (Gym@AuNPs) was synthesised by eco-friendly approach. The synthesised Gym@AuNPs was confirmed by the colour change from light yellow to a deep ruby red. UV − visible spectroscopy results showed a strong narrow peak at 530 nm, confirming the controlled synthesis of monodispersed Gym@AuNPs. The reduction potential of standard Gymnemic acid (Gym) on synthesis of Gym@AuNPs was confirmed by using HPLC analysis. The spherical shaped Gym@AuNPs was observed by FESEM and HR-TEM studies with average size of 48.52 ± 5.53 nm. The XRD analysis exhibited a face-centered cubic (FCC) crystalline nature of Gym@AuNPs. The in vivo antidiabetic activity of Gym and Gym@AuNPs were validated using Streptozotocin induced diabetic Albino wistar rats. The Gym@AuNPs and Gym were regulates the glucose and lipid levels in experimental animals. The histopathology outcomes shown that the Gym@AuNPs were restoration of pancreatic islets cells in the animals. This investigation demonstrated that the Gym@AuNPs had the potential anti-diabetic properties.

Item Type:	Journal Article
Publication:	International Journal of Pharmaceutics
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Keywords:	Antihyperglycemic Activity; Gym@AuNPs; HPLC analysis
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	03 Apr 2023 09:40
Last Modified:	03 Apr 2023 09:40
URI:	https://eprints.iisc.ac.in/id/eprint/81148

Actions (login required)

View Item