Hinged Bipodal Furoylthiourea-Based Ru(II)-Arene Complexes: Effect of (ortho, meta, or para)-Substitution on Coordination and Anticancer Activity

Swaminathan, S and Haribabu, J and Dharmasivam, M and Maroli, N and Jayadharini, JP and Balakrishnan, N and Bhuvanesh, N and Echeverria, C and Karvembu, R (2023) Hinged Bipodal Furoylthiourea-Based Ru(II)-Arene Complexes: Effect of (ortho, meta, or para)-Substitution on Coordination and Anticancer Activity. In: Inorganic Chemistry .

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Abstract

We set out to design and synthesize bipodal ligands with the phenyl group as the spacer and varied the substitution on the spacer between ortho (L1), meta (L2), and para (L3). The respective ligands and complexes containing either p-cymene (PL1-PL3) or benzene (BL1-BL3) as the arene unit were synthesized and characterized successfully. The influence of the ligands due to substitution change on their coordination behavior was quite minimal; however, the differences were seen in the anticancer activity of the complexes. DFT studies revealed the structural variations between the three different substitutions, which was further confirmed by single-crystal X-ray diffraction studies. The anticancer activity of the complexes could be correlated with their rate of hydrolysis and their lipophilicity index as determined by UV-visible spectroscopy. The cell death mechanism of the active complexes was deduced to be apoptotic via staining assays, flow cytometry, and Western blot analysis. © 2023 American Chemical Society.

Item Type:	Journal Article
Publication:	Inorganic Chemistry
Publisher:	American Chemical Society
Additional Information:	The copyright of this article belongs to American Chemical Society.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	10 Mar 2023 10:45
Last Modified:	10 Mar 2023 10:45
URI:	https://eprints.iisc.ac.in/id/eprint/80957

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