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Design and development of a functional diffuse optical tomography probe for real-time 3D imaging of tissue

Saikia, MJ (2021) Design and development of a functional diffuse optical tomography probe for real-time 3D imaging of tissue. In: Optical Tomography and Spectroscopy of Tissue XIV 2021, 6 - 11 March 2021, Virtual, Online.

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Official URL: https://doi.org/10.1117/12.2577433

Abstract

Diffuse optical tomography is a non-invasive medical imaging method that quantitatively reconstructs three-dimensional optical absorption and scattering coefficient distribution of imaging tissue domain. Functional diffuse optical tomography (fDOT) system uses multiple-wavelength near-infrared (NIR) light sources, and by reconstructing the variation of the absorption coefficient inside the tissue for these wavelengths, it maps the concentration of various constituents such as oxygenated and deoxygenated blood, water and lipids inside the tissue. This manuscript discusses the development of a 3D tissue scanning system based on fDOT principle. A configurable optical fiber probe was designed that can be placed on a tissue surface to inject modulated NIR light into the tissue from one of the three wavelengths (660, 735, and 850 nm) by light-emitting diodes (LED). The intensity of the back-reflected diffused light is measured using detector fibers coupled with a set of photodetectors. A microcontroller-based electronic circuit system and a dedicated DAQ unit perform system control, data acquisition, noise-free lock-in detection, and wireless data transmission to a host computer, equipped with a graphics processing unit (GPU). The GPU system executes a 3D fDOT spectroscopic image reconstruction software in real-time. Extensive simulation studies have been carried out for the 3D fDOT image reconstruction to study the concentration of chromophores such as oxyhemoglobin, deoxyhemoglobin, and water, and to characterize tumor located deep inside the tissue. The results from two different experimental setups validated the system. The promising results pave the way for the development of a low-cost 3D fDOT handheld system for the real-time onsite functional imaging of biological tissue. © 2021 SPIE

Item Type: Conference Paper
Publication: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher: SPIE
Additional Information: The copyright for this article belongs to SPIE.
Keywords: Chromophores; Computer control systems; Computer graphics; Computer graphics equipment; Data acquisition; Graphics processing unit; Image reconstruction; Imaging systems; Infrared devices; Light absorption; Light sources; Medical imaging; Optical fibers; Optical tomography; Probes; Program processors; Tissue; Water absorption, Absorption and scatterings; Absorption co-efficient; Design and Development; Diffuse optical tomography; Electronic circuit system; Microcontroller-based; Reconstruction software; Wireless data transmission, Tissue engineering
Department/Centre: Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited: 09 Mar 2023 06:30
Last Modified: 09 Mar 2023 06:30
URI: https://eprints.iisc.ac.in/id/eprint/80885

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