Musib, D and Raza, MK and Pal, M and Roy, M (2021) A red light-activable MnI(CO)3-functionalized gold nanocomposite as the anticancer prodrug with theranostic potential. In: Applied Organometallic Chemistry, 35 (2).
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Abstract
The controlled and target-specific release of CO to a target site upon photoactivation has recently emerged as a promising tool for targeted anticancer activity. However, the present CO-releasing molecules (CORMs) suffer several limitations, including poor delivery to the tumor site. In this study, we reported the synthesis, characterization, and caspase 3/7-dependent apoptosis (IC50: 232 μg ml−1 or 29.03 nM) in A549 cells by manganese(I) carbonyl-functionalized gold nanoparticles (1-AuNPs) on dual photosensitization in red light (600–720 nm, 30 J cm−2). The 1-AuNPs, however, remained nontoxic to A549 cells in the dark. The Mn(I)–CO complex (1) exhibited photocytotoxicity (IC50: 38.1 μM in red light; IC50: 88 μM in dark) as well. Dual photosensitization with red light leading to rapid, synergic CO release and singlet oxygen (1O2) generation were the principal mechanism for the photocytotoxicity, which was studied in detail. Photoactivated CO release resulted in TURN-ON luminescence in A549 cells and renders the hybrid 1-AuNPs an ideal, next-generation nanotheranostic agent.
Item Type: | Journal Article |
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Publication: | Applied Organometallic Chemistry |
Publisher: | John Wiley and Sons Ltd |
Additional Information: | The copyright for this article belongs to John Wiley and Sons Ltd. |
Keywords: | Cell death; Gold nanoparticles; Light; Synthesis (chemical); Theranostics, Anticancer activities; Co complexes; Functionalized gold nanoparticles; Gold nanocomposites; Photo activations; Photo-activated; Photocytotoxicity; Singlet oxygen, Manganese compounds |
Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
Date Deposited: | 16 Feb 2023 10:34 |
Last Modified: | 16 Feb 2023 10:34 |
URI: | https://eprints.iisc.ac.in/id/eprint/80528 |
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