Use of biocompatible natural product ‘quinine’ for naked-eye sensing of Sarin-surrogate both in solution-state and vapor phase

Dey, N (2021) Use of biocompatible natural product ‘quinine’ for naked-eye sensing of Sarin-surrogate both in solution-state and vapor phase. In: Journal of Molecular Liquids, 327 .

PDF jou_mol_liq_327_2021.pdf - Published Version Restricted to Registered users only Download (2MB) | Request a copy

Abstract

A fluorescent, biocompatible natural product, quinine (commercially available at low-cost), has been employed for ratiometric, dual-mode sensing of diethyl chlorophosphate (DCP, a sarin surrogate) in the aqueous medium (using pH 7.0 buffer). The addition of DCP induces a rapid (< 30s) change in solution color from colorless to yellow, accompanied by an appearance of intense blue-colored fluorescence (detection limit: 18 nM). Mechanistic investigation indicates phosphorylation of the hydroxyl unit of quinine in the presence of DCP, followed by protonation at the quinoline nitrogen end. The chemodosimetric adduct, so formed, possesses a conformationally-locked structure with a significantly different charge-transfer state as compared to the parent molecule. Such a bifunctional labeling reaction is found to be highly selective towards DCP, no other warfare chemicals, including diethyl cyanophosphate (DCNP, a tabun surrogate) could render any detectable interference. Further, a solid-supported sensing device has been designed as a sustainable strategy for on-site vapor phase detection of DCP. © 2020 Elsevier B.V.

Item Type:	Journal Article
Publication:	Journal of Molecular Liquids
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Keywords:	Charge transfer; Costs; Fluorescence, Charge transfer state; Detection limits; Diethyl chlorophosphate; Hydroxyl units; Natural products; Parent molecules; Sensing devices; Sustainable strategies, Biocompatibility
Department/Centre:	Division of Physical & Mathematical Sciences > Centre for Theoretical Studies (Ceased to exist at the end of 2003)
Date Deposited:	20 Feb 2023 10:57
Last Modified:	20 Feb 2023 10:57
URI:	https://eprints.iisc.ac.in/id/eprint/80413

Actions (login required)

View Item