Modulation of Redox Signaling and Thiol Homeostasis in Red Blood Cells by Peroxiredoxin Mimetics

Chakrabarty, G and Naveenkumar, SK and Kumar, S and Mugesh, G (2020) Modulation of Redox Signaling and Thiol Homeostasis in Red Blood Cells by Peroxiredoxin Mimetics. In: ACS Chemical Biology, 15 (10). pp. 2673-2682.

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Abstract

Red blood cell death or erythrocyte apoptosis (eryptosis) is generally mediated by oxidative stress, energy depletion, heavy metals exposure, or xenobiotics. As erythrocytes are a major target for oxidative stress due to their primary function as O2-carrying cells, they possess an efficient antioxidant defense system consisting of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and peroxiredoxin 2 (Prx2). The oxidative stress-mediated activation of the Ca2+-permeable cation channel results in Ca2+ entry into the cells and subsequent cell death. Herein, we describe for the first time that selenium compounds having intramolecular diselenide or selenenyl sulfide moieties can prevent the oxidative stress-induced eryptosis by exhibiting an unusual Prx2-like redox activity under conditions when the cellular Prx2 and CAT enzymes are inhibited. Copyright © 2020 American Chemical Society.

Item Type:	Journal Article
Publication:	ACS Chemical Biology
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society.
Keywords:	catalase; diselenide; glutathione reductase; hydrogen peroxide; organoselenium derivative; peroxiredoxin 2; selenenyl sulfide; selenium derivative; thiol; thioredoxin; thioredoxin reductase; unclassified drug; antioxidant; organoselenium derivative; peroxiredoxin; thioredoxin; TXN protein, human, antioxidant activity; Article; calcium cell level; cell protection; cell viability; confocal microscopy; controlled study; cytotoxicity; eryptosis; flow cytometry; hematocrit; homeostasis; human; human cell; oxidative stress; priority journal; protein expression; protein purification; signal transduction; chemistry; drug effect; eryptosis; erythrocyte; homeostasis; metabolism; oxidation reduction reaction; oxidative stress; signal transduction, Antioxidants; Eryptosis; Erythrocytes; Homeostasis; Humans; Organoselenium Compounds; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Signal Transduction; Thioredoxins
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	11 Feb 2023 03:47
Last Modified:	11 Feb 2023 03:47
URI:	https://eprints.iisc.ac.in/id/eprint/80183

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