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Mannose: a potential saccharide candidate in disease management

Dhanalakshmi, M and Sruthi, D and Jinuraj, KR and Das, K and Dave, S and Andal, NM and Das, J (2023) Mannose: a potential saccharide candidate in disease management. In: Medicinal Chemistry Research .

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Official URL: https://doi.org/10.1007/s00044-023-03015-z


There are a plethora of antibiotic resistance cases and humans are marching towards another big survival test of evolution along with drastic climate change and infectious diseases. Ever since the first antibiotic penicillin, and the myriad of vaccines, we were privileged to escape many infectious disease threats. The survival technique of pathogens seems rapidly changing and sometimes mimicking our own systems in such a perfect manner that we are left unarmed against them. Apart from searching for natural alternatives, repurposing existing drugs more effectively is becoming a familiar approach to new therapeutic opportunities. The ingenious use of revolutionary artificial intelligence-enabled drug discovery techniques is coping with the speed of such alterations. D-Mannose is a great hope as a nutraceutical in drug discovery, against CDG, diabetes, obesity, lung disease, and autoimmune diseases and recent findings of anti-tumor activity make it interesting along with its role in drug delivery enhancing techniques. A very unique work done in the present investigation is the collection of data from the ChEMBL database and presenting the targetable proteins on pathogens as well as on humans. It shows Mannose has 50 targets and the majority of them are on human beings. The structure and conformation of certain monosaccharides have a decisive role in receptor pathogen interactions and here we attempt to review the multifaceted roles of Mannose sugar, its targets associated with different diseases, as a natural molecule having many success stories as a drug and future hope for disease management. Graphical abstract: Figure not available: see fulltext.

Item Type: Journal Article
Publication: Medicinal Chemistry Research
Publisher: Springer
Additional Information: The copyright for this article belongs to the Authors.
Keywords: Antibiotic; Congenital disorder of glycosylation (CDG); Drug delivery; Immune regulation; Mannose; Urinary tract infections
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 07 Feb 2023 07:22
Last Modified: 07 Feb 2023 07:22
URI: https://eprints.iisc.ac.in/id/eprint/80153

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