Thermoresponsive sustainable release of anticancer drugs using cyto-compatible pyrenylated hydrogel as vehicle

Biswakarma, D and Dey, N and Bhattacharya, S (2023) Thermoresponsive sustainable release of anticancer drugs using cyto-compatible pyrenylated hydrogel as vehicle. In: Journal of Chemical Sciences, 135 (1).

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Abstract

Pyrene-based fluorogenic amphiphilic probe (1) has been synthesized, which can form a thixotropic (injectable) hydrogel in the aqueous medium. The biocompatible hydrogel, so formed, is involved in the thermoresponsive, sustainable delivery of two anticancer drugs, Doxorubicin (DOX) and Mitoxantrone (MT). A substantial difference in the extent of drug release is noticed at 25 and 37 °C, even at physiological pH. The cumulative releases of ~80 and ~70 for DOX and MT, respectively, from the drug-loaded hydrogel samples, are observed for 72 h. In both cases, drug molecule release follows zero-order kinetics and non-Fickian diffusion pathways. The excellent stability of 1 against proteinase enzyme suggests that the present system can be used for sustainable, targeted release of drug molecules under in-vivo conditions. As expected, DOX-loaded hydrogels kill cancer cells more efficiently than the free drug (i.e., DOX). Graphical abstract: A pyrene-based amphiphilic probe has been synthesized, which can form a thixotropic hydrogel in the aqueous medium. The biocompatible hydrogel was involved in the thermoresponsive, sustainable delivery of two anticancer drugs, Doxorubicin (DOX) and Mitoxantrone (MT). Moreover, the DOX-loaded hydrogel could kill cancer cells more efficiently than the free drug.Figure not available: see fulltext.. © 2023, Indian Academy of Sciences.

Item Type:	Journal Article
Publication:	Journal of Chemical Sciences
Publisher:	Springer
Additional Information:	The copyright for this article belongs to Springer.
Keywords:	Biocompatibility; Cancer cells; Cells; Controlled drug delivery; Diseases; Molecules; pH; Probes; Pyrene; Targeted drug delivery, Amphiphilics; Anticancer drug; Cytocompatibility; Doxorubicin; Drug-loaded hydrogel; Mitoxantrone; Sustainable delivery; Thermo responsiveness; Thermo-responsive; Thixotropic behaviour, Hydrogels
Department/Centre:	Division of Chemical Sciences > Organic Chemistry Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	10 Feb 2023 04:20
Last Modified:	10 Feb 2023 04:20
URI:	https://eprints.iisc.ac.in/id/eprint/80137

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