Proteoglycan desulfation: A critical step in oncogenesis?

Singh, V and Bhat, R (2020) Proteoglycan desulfation: A critical step in oncogenesis? In: Frontiers in Bioscience - Landmark, 25 (4). pp. 760-780.

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Abstract

Proteoglycans are essential constituents of tissue- and organ microenvironments, modulating both the structural scaffolds that surround cells as well as signaling cues that determine cellular phenotype. An important modification of proteoglycans is the sulfation of the monosaccharides that comprise them. Sulfates are added by sulfotransferases and desulfation occurs through the action of sulfatases. In this essay, we examine the biochemistry of a conserved family of desulfating enzymes known as arylsulfatases. A subset of these enzymes mediates the desulfation of proteoglycans. We review the consequences of their aberrant expression in the light of carcinogenesis and carcinomatosis: the dissemination of cancer cells. A closer understanding of their cellular-molecular roles reveals their promise for future strategies for cancer therapy. © 2020 Frontiers in Bioscience. All rights reserved.

Item Type:	Journal Article
Publication:	Frontiers in Bioscience - Landmark
Publisher:	Frontiers in Bioscience
Additional Information:	The copyright for this article belongs to Frontiers in Bioscience.
Keywords:	arylsulfatase; proteoglycan; sulfatase; sulfate; sulfotransferase, animal; carcinogenesis; epithelial mesenchymal transition; human; metabolism; signal transduction, Animals; Arylsulfatases; Carcinogenesis; Epithelial-Mesenchymal Transition; Humans; Proteoglycans; Signal Transduction; Sulfatases; Sulfates; Sulfotransferases
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	08 Feb 2023 11:23
Last Modified:	08 Feb 2023 11:23
URI:	https://eprints.iisc.ac.in/id/eprint/80082

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