N-Heterocyclic Carbene (NHC)-Catalyzed Transformations for the Synthesis of Heterocycles

Das, TK and Biju, AT (2020) N-Heterocyclic Carbene (NHC)-Catalyzed Transformations for the Synthesis of Heterocycles. [Book Chapter]

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Abstract

N-heterocyclic carbene (NHC)-based organocatalysis has been widely used for unconventional access to various target molecules. The use of chiral NHCs in the process results in the enantioselective synthesis of various heterocycles. The underlying principle of many of the NHC-catalyzed reactions is the remarkable ability of NHCs to reverse the normal mode of reactivity of aldehydes (umpolung). NHCs can catalyze transformations proceeding via the umpolung or nonumpolung mode for the synthesis of various functionalized molecules. The recent advances in the application of NHCs for the synthesis of various heterocyclic compounds are highlighted in this chapter. © 2020 Elsevier Ltd

Item Type:	Book Chapter
Publication:	Progress in Heterocyclic Chemistry
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd.
Keywords:	Aldimine umpolung; Benzoin reaction; Breslow intermediates; Enantioselective synthesis; Heterocyclic synthesis, aldehyde umpolung; N-Heterocyclic carbene; Stetter reaction
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	08 Feb 2023 11:02
Last Modified:	08 Feb 2023 11:02
URI:	https://eprints.iisc.ac.in/id/eprint/80081

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