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Identification of compounds for improved growth of Leptospira in culture and isolation

Dhayabaran, V and Chidambaram, D and Krishnaswamy, PR (2020) Identification of compounds for improved growth of Leptospira in culture and isolation. In: Diagnostic Microbiology and Infectious Disease, 96 (1).

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Official URL: https://doi.org/10.1016/j.diagmicrobio.2019.114923


Leptospirosis is a recurring global disease of severe illness involving pulmonary and renal involvement in cattle and humans that needs attention to cure. The major challenge in treating leptospirosis disease is the diagnosis of the disease. The culturing of an organism is a gold standard for confirmation of the disease. The growth and optimistic identification of an organism require at least 8 to 14 days because of its slow growth characteristics. We have investigated various media conditions that are prepared based on the wealth of information obtained from ‘omic’ studies and report a sustainable Leptospira growth medium comprising of serum equivalent elements and nutrients for pyrimidine biosynthesis, which allows a visible growth of organism within 2 days.

Item Type: Journal Article
Publication: Diagnostic Microbiology and Infectious Disease
Publisher: Elsevier Inc.
Additional Information: The copyright for this article belongs to Elsevier Inc.
Keywords: element; pyrimidine, Article; bacterial growth; bacterium culture; bacterium identification; bacterium isolation; Leptospira; nonhuman; nutrient; priority journal; pyrimidine synthesis; chemistry; culture medium; growth, development and aging; isolation and purification; Leptospira; microbiological examination; serum-free medium; time factor, Bacteriological Techniques; Culture Media; Culture Media, Serum-Free; Leptospira; Time Factors
Department/Centre: Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited: 08 Feb 2023 08:52
Last Modified: 08 Feb 2023 08:52
URI: https://eprints.iisc.ac.in/id/eprint/80067

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