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Manoeuvring protein functions and functional levels by structural excursions

Prabantu, VM and Yazhini, A and Srinivasan, N (2020) Manoeuvring protein functions and functional levels by structural excursions. [Book Chapter]

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Official URL: https://doi.org/10.1016/B978-0-12-817996-3.00006-2


The discovery of moonlighting proteins has opened the paradigm of one protein with many functions. Proteins can switch their functions or functional levels through cellular environmental cues and structural changes without altering their amino acid sequences. This chapter describes how three-dimensional (3D) structural features influence protein functions, in a cellular context. It reviews on the implications of factors such as protein-protein interactions, interactions among domains within a multidomain protein, posttranslational modifications, and synonymous codon substitutions on protein functions. Instances of these aspects highlight how cellular environment and 3D structure govern protein actions. Changes in protein functions or functional levels mediated by such nongenetic factors are associated with phenotypic differences related to viral infection, survival in methanol source, cell division, inflammation, and melanoma. Thus, the participation of diverse factors in the regulation of protein function increases complexity to the understanding of cellular mechanisms.

Item Type: Book Chapter
Publication: Phenotypic Switching: Implications in Biology and Medicine
Publisher: Elsevier
Additional Information: The copyright for this article belongs to Elsevier.
Keywords: Domain-domain interactions; Modulation of functions; Moonlighting proteins; Posttranslation modifications; Protein-protein interactions; Synonymous mutations
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 07 Feb 2023 04:04
Last Modified: 07 Feb 2023 04:04
URI: https://eprints.iisc.ac.in/id/eprint/79963

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