Epithelial-mesenchymal transition in cancer

Jia, D and Jolly, MK and Levine, H and Onuchic, JN (2020) Epithelial-mesenchymal transition in cancer. [Book Chapter]

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Abstract

The epithelial-mesenchymal transition (EMT) functions as a central regulator of processes that help enable metastasis. Cancer cells undergoing EMT can acquire a spectrum of hybrid epithelial/mesenchymal (E/M) phenotypes characterized by varying degrees of combined epithelial and mesenchymal features. Cells in the hybrid E/M phenotypes can migrate collectively as a cluster. Clusters of migrating tumor cells are a major contributor to metastases. Therefore, identifying the molecular mechanisms underlying the emergence of the hybrid E/M phenotypes can imply critical clues for anti-metastasis therapeutic design. To that end, both computational and experimental approaches have been developed to characterize the hybrid E/M phenotypes and to elucidate cancer epithelial-mesenchymal plasticity, that is, the ability to switch between epithelial, mesenchymal and hybrid E/M phenotypes. EMT serves as an example of cellular plasticity, which leads to cancer nongenetic heterogeneity.

Item Type:	Book Chapter
Publication:	Phenotypic Switching: Implications in Biology and Medicine
Publisher:	Elsevier
Additional Information:	The copyright for this article belongs to Elsevier.
Keywords:	Abnormal attractors; EMT; Epithelial-mesenchymal transition; Hybrid epithelial/mesenchymal phenotype; Metastasis; Phenotypic stability factors; Systems biology; Therapy resistance Abnormal attractors; EMT; Epithelial-mesenchymal transition; Hybrid epithelial/mesenchymal phenotype; Metastasis; Phenotypic stability factors; Systems biology; Therapy resistance Abnormal attractors; EMT; Epithelial-mesenchymal transition; Hybrid epithelial/mesenchymal phenotype; Metastasis; Phenotypic stability factors; Systems biology; Therapy resistance
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	06 Feb 2023 10:27
Last Modified:	06 Feb 2023 10:27
URI:	https://eprints.iisc.ac.in/id/eprint/79960

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