Dampened X-chromosomes in human pluripotent stem cells: dampening or erasure of X-upregulation?

Kaur, H and Rv, P and Gayen, S (2020) Dampened X-chromosomes in human pluripotent stem cells: dampening or erasure of X-upregulation? In: Chromosoma, 129 (2). pp. 111-113.

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Abstract

The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of X-chromosome dampening in human naïve pluripotent stem cells (hPSCs) as well. Here, we discuss whether X-dampening reported in hPSCs truly reflects the dampening of X-chromosomes or it is a consequence of the erasure of X-chromosome upregulation.

Item Type:	Journal Article
Publication:	Chromosoma
Publisher:	Springer
Additional Information:	The copyright for this article belongs to Springer.
Keywords:	embryo; human; human cell; human embryo; pluripotent stem cell; review; upregulation; X chromosome inactivation; animal; cytology; embryo development; gene dosage; gene expression regulation; genetics; metabolism; pluripotent stem cell; upregulation; X chromosome, Animals; Chromosomes, Human, X; Dosage Compensation, Genetic; Embryonic Development; Gene Dosage; Gene Expression Regulation; Humans; Pluripotent Stem Cells; Up-Regulation
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	06 Feb 2023 07:26
Last Modified:	06 Feb 2023 07:26
URI:	https://eprints.iisc.ac.in/id/eprint/79889

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