Preparation and characterization of bioactive silk fibroin/paramylon blend films for chronic wound healing

Arthe, R and Arivuoli, D and Ravi, V (2020) Preparation and characterization of bioactive silk fibroin/paramylon blend films for chronic wound healing. In: International Journal of Biological Macromolecules, 154 . pp. 1324-1331.

PDF Int_Jou_Bio_154_1324-1331_2020.pdf - Published Version Restricted to Registered users only Download (2MB) | Request a copy

Abstract

A major challenge in the chronic wound healing is a self-care wound dressing. The problem in chronic wounds is the lack of functional extracellular matrix to stimulate healing. The extracellular matrix is a network of proteins and polysaccharides that serves as physical framework and provides regulatory signals. The primary goal is to mimic the property of the extracellular matrix with Silk Fibroin and Paramylon to produce a novel bioactive film. Silk fibroin is a fibrous protein having unique mechanical properties and tunable biodegradability that makes it favourable for tailoring to specific applications. Paramylon is a β-glucan that possess a broad spectrum of biological activity that enhances the immune response. Silk fibroin/paramylon blend films have been prepared by solution casting and were examined for structural, thermal, mechanical and other physical properties for knowing its transformation for chronic wound healing. It was observed that the fibroin films shows high thermal stability, high hydrophobicity, high stiffness value whereas the paramylon film show good water absorption property and both fibroin and paramylon shows good blood compatibility and was non-toxic as well. It also confirms that the blended films showed a combination of fibroin and paramylon property at different concentrations without any chemical interaction.

Item Type:	Journal Article
Publication:	International Journal of Biological Macromolecules
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Keywords:	beta glucan; paramylon; silk fibroin; unclassified drug; biomaterial; fibroin; glucan; paramylon; water, Article; biocompatibility; biomechanics; biotransformation; cell viability; contact angle; controlled study; embryo; enzyme degradation; hemolysis; human; human cell; hydrophobicity; in vitro study; rigidity; thermostability; water absorption; wettability; wound healing; animal; chemistry; drug effect; materials testing; mechanics; wound healing, Animals; Biocompatible Materials; Fibroins; Glucans; Hemolysis; Humans; Materials Testing; Mechanical Phenomena; Water; Wound Healing
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	06 Feb 2023 06:41
Last Modified:	06 Feb 2023 06:41
URI:	https://eprints.iisc.ac.in/id/eprint/79860

Actions (login required)

View Item