Delayed Fluorescence, Room Temperature Phosphorescence, and Mechanofluorochromic Naphthalimides: Differential Imaging of Normoxia and Hypoxia Live Cancer Cells

Jena, S and Dhanalakshmi, P and Bano, G and Thilagar, P (2020) Delayed Fluorescence, Room Temperature Phosphorescence, and Mechanofluorochromic Naphthalimides: Differential Imaging of Normoxia and Hypoxia Live Cancer Cells. In: Journal of Physical Chemistry B, 124 (26). pp. 5393-5406.

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Abstract

We study the effect of molecular conformation on the electronic coupling between the donor amines and acceptor 1,8-naphthalimide (NPI) in a series of D-A systems 1-4 (A = NPI; D = phenothiazine, phenoxazine, carbazole, diphenylamine, respectively, for 1, 2, 3, and 4). Weakly coupled systems show dual emission in the solution state, while strongly coupled systems show single emission bands. The energy of transitions and photoluminescence (PL) quantum yield are sensitive to the molecular conformation and donor strength. These compounds show delayed emission in the solutions and aggregated state and phosphorescence in the solid state. Compounds 3 and 4 with weak donors exhibit intermolecular slipped ···πinteractions in the solid state and consequently exhibit dual (intra- and inter-) phosphorescence at low temperature. Steady state and time-resolved PL studies at variable temperature together with computational and crystal structure analysis were used to rationalize the optical properties of these compounds. The delayed emission of these compounds is sensitive to molecular oxygen; accordingly, these molecules are utilized for differential imaging of normoxia and hypoxia cancer cells. Copyright © 2020 American Chemical Society.

Item Type:	Journal Article
Publication:	Journal of Physical Chemistry B
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society.
Keywords:	Amines; Cells; Conformations; Diseases; Fluorescence; Molecular oxygen; Optical properties; Phosphorescence; Temperature, 1 , 8-naphthalimide; Crystal structure analysis; Delayed fluorescence; Electronic coupling; Molecular conformation; Room temperature phosphorescence; Variable temperature; Weakly coupled systems, Crystal structure, naphthalimide derivative, fluorescence; human; hypoxia; luminescence; neoplasm; temperature, Fluorescence; Humans; Hypoxia; Luminescence; Naphthalimides; Neoplasms; Temperature
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	03 Feb 2023 05:14
Last Modified:	03 Feb 2023 05:14
URI:	https://eprints.iisc.ac.in/id/eprint/79830

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