Base excision repair pathways of bacteria: New promise for an old problem

Kurthkoti, K and Kumar, P and Sang, PB and Varshney, U (2020) Base excision repair pathways of bacteria: New promise for an old problem. In: Future Medicinal Chemistry, 12 (4). pp. 339-355.

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Abstract

Infectious diseases continue to be a major cause of human mortality. With the emergence of drug resistance, diseases that were long thought to have been curable by antibiotics are resurging. There is an urgent clinical need for newer antibiotics that target novel cellular pathways to overcome resistance to currently used therapeutics. The base excision repair (BER) pathways of the pathogen restore altered bases and safeguard the genomic integrity of the pathogen from the host's immune response. Although the BER machinery is of paramount importance to the survival of the pathogens, its potential as a drug target is largely unexplored. In this review, we discuss the importance of BER in different pathogenic organisms and the potential of its inhibition with small molecules. © 2020 Newlands Press.

Item Type:	Journal Article
Publication:	Future Medicinal Chemistry
Publisher:	Future Medicine Ltd.
Additional Information:	The copyright for this article belongs to the Future Medicine Ltd.
Keywords:	adenosine triphosphate; antiinfective agent; cgp 74514a; crt 0044876; DNA; DNA glycosylase MutY; DNA glycosyltransferase; enzyme inhibitor; reactive oxygen metabolite; tb 820; unclassified drug; uracil; antiinfective agent, alkylation; bacterium; deamination; DNA damage; DNA repair; drug design; drug development; drug structure; drug targeting; Escherichia coli; excision repair; Helicobacter pylori; infection; molecular docking; molecularly targeted therapy; Mycobacterium tuberculosis; nonhuman; oxidation; Plasmodium falciparum; priority journal; Pseudomonas aeruginosa; Review; Salmonella enterica serovar Typhimurium; antibiotic resistance; bacterium; chemistry; communicable disease; drug effect; human; metabolism; microbial sensitivity test; molecular library; pharmacology, Anti-Bacterial Agents; Bacteria; Communicable Diseases; DNA Damage; DNA Repair; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Small Molecule Libraries
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	02 Feb 2023 07:20
Last Modified:	02 Feb 2023 07:20
URI:	https://eprints.iisc.ac.in/id/eprint/79737

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