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Pharmacological Tools to Modulate Autophagy in Neurodegenerative Diseases

Suresh, SN and Chakravorty, A and Giridharan, M and Garimella, L and Manjithaya, R (2020) Pharmacological Tools to Modulate Autophagy in Neurodegenerative Diseases. In: Journal of Molecular Biology, 432 (8). pp. 2822-2842.

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Official URL: https://doi.org/10.1016/j.jmb.2020.02.023


Considerable evidences suggest a link between autophagy dysfunction, protein aggregation, and neurodegenerative diseases. Given that autophagy is a conserved intracellular housekeeping process, modulation of autophagy flux in various model organisms have highlighted its importance for maintaining proteostasis. In postmitotic cells such as neurons, compromised autophagy is sufficient to cause accumulation of ubiquitinated aggregates, neuronal dysfunction, degeneration, and loss of motor coordination-all hallmarks of neurodegenerative diseases. Reciprocally, enhanced autophagy flux augments cellular and organismal health, in addition to extending life span. These genetic studies not-withstanding a plethora of small molecule modulators of autophagy flux have been reported that alleviate disease symptoms in models of neurodegenerative diseases. This review summarizes the potential of such molecules to be, perhaps, one of the first autophagy drugs for treating these currently incurable diseases

Item Type: Journal Article
Publication: Journal of Molecular Biology
Publisher: Academic Press
Additional Information: The copyright for this article belongs to the Academic Press.
Keywords: agents acting on the peripheral nervous and neuromuscular systems; beclin 1; calcium channel L type; cyclic AMP; hydroxymethylglutaryl coenzyme A reductase kinase; mammalian target of rapamycin; transcription factor; transcription factor EB; unclassified drug, aggrephagy; aging; Alzheimer disease; amyotrophic lateral sclerosis; autophagy (cellular); biogenesis; degenerative disease; human; Huntington chorea; lysosome; mitophagy; nonhuman; Parkinson disease; pathogenesis; priority journal; protein aggregation; protein degradation; protein homeostasis; Review; signal transduction; animal; autophagy; degenerative disease; molecular library; pathology; pharmacology; proteinosis, Animals; Autophagy; Humans; Neurodegenerative Diseases; Protein Aggregation, Pathological; Small Molecule Libraries
Department/Centre: Autonomous Societies / Centres > Centre for Brain Research
Date Deposited: 01 Feb 2023 06:23
Last Modified: 01 Feb 2023 06:23
URI: https://eprints.iisc.ac.in/id/eprint/79665

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