Ghosh, A and Jayaraman, N and Chatterji, D (2020) Small-Molecule Inhibition of Bacterial Biofilm. In: ACS Omega, 5 (7). pp. 3108-3115.
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Abstract
Antibiotic resistance is a massive and serious threat to human welfare and healthcare. Apart from being genetically resistant to antibiotics, the other important mechanism by which bacteria can evade antibiotics is multidrug tolerance. Here cells enter into a transiently nongrowing phase, and as a result, latent infection remains inside the host, causing disease recurrence. Biofilm-derived antibiotic tolerance and persister formation of the pathogenic bacteria inside the host remain a serious issue of treatment failure and recurrent chronic infection in the case of all major pathogens. As a result, new chemotherapeutic agents are sought that specifically inhibit biofilm formation or maturation as well as cause the dispersion of mature biofilms, thus allowing the conventional drugs to kill sensitive cells residing inside. This mini-review attempts to analyze different small-molecule-based chemical approaches that have been used to enable bacterial biofilm inhibition at different steps of maturation. © 2020 American Chemical Society.
| Item Type: | Journal Article |
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| Publication: | ACS Omega |
| Publisher: | American Chemical Society |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | Cobalt compounds; Cost effectiveness; Drain current; Electric discharges; Electrocatalysts; Electrodes; Electrolytic reduction; Oxygen; Phosphorus compounds; Pyrites; Solid electrolytes; Sulfur compounds; Zinc, Bi-functional catalysts; Bifunctional electrocatalysts; Four-electron reduction; Gel electrolyte; Oxygen evolution reaction; Oxygen reduction reaction; Precious metal catalysts; Rechargeable zinc-air batteries, Zinc air batteries |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 24 Jan 2023 11:17 |
| Last Modified: | 24 Jan 2023 11:17 |
| URI: | https://eprints.iisc.ac.in/id/eprint/79430 |
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