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Emerging nanophotonic biosensor technologies for virus detection

Bannur Nanjunda, S and Seshadri, VN and Krishnan, C and Rath, S and Arunagiri, S and Bao, Q and Helmerson, K and Zhang, H and Jain, R and Sundarrajan, A and Srinivasan, B (2022) Emerging nanophotonic biosensor technologies for virus detection. In: Nanophotonics, 11 (22). 5041 -5059.

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Official URL: https://doi.org/10.1515/nanoph-2022-0571


Highly infectious viral diseases are a serious threat to mankind as they can spread rapidly among the community, possibly even leading to the loss of many lives. Early diagnosis of a viral disease not only increases the chance of quick recovery, but also helps prevent the spread of infections. There is thus an urgent need for accurate, ultrasensitive, rapid, and affordable diagnostic techniques to test large volumes of the population to track and thereby control the spread of viral diseases, as evidenced during the COVID-19 and other viral pandemics. This review paper critically and comprehensively reviews various emerging nanophotonic biosensor mechanisms and biosensor technologies for virus detection, with a particular focus on detection of the SARS-CoV-2 (COVID-19) virus. The photonic biosensing mechanisms and technologies that we have focused on include: (a) plasmonic field enhancement via localized surface plasmon resonances, (b) surface enhanced Raman scattering, (c) nano-Fourier transform infrared (nano-FTIR) near-field spectroscopy, (d) fiber Bragg gratings, and (e) microresonators (whispering gallery modes), with a particular emphasis on the emerging impact of nanomaterials and two-dimensional materials in these photonic sensing technologies. This review also discusses several quantitative issues related to optical sensing with these biosensing and transduction techniques, notably quantitative factors that affect the limit of detection (LoD), sensitivity, specificity, and response times of the above optical biosensing diagnostic technologies for virus detection. We also review and analyze future prospects of cost-effective, lab-on-a-chip virus sensing solutions that promise ultrahigh sensitivities, rapid detection speeds, and mass manufacturability. © 2022 the author(s), published by De Gruyter, Berlin/Boston 2022.

Item Type: Journal Article
Publication: Nanophotonics
Publisher: De Gruyter Open Ltd
Additional Information: The copyright for this article belongs to the Author(s).
Keywords: Biosensors; Cost effectiveness; Diagnosis; Disease control; Fiber Bragg gratings; Fourier series; Fourier transform infrared spectroscopy; Nanophotonics; Optical resonators; Raman scattering; Surface scattering; Whispering gallery modes, Biosensing; Diagnostics techniques; Early diagnosis; Healthcare; Nano or two-dimensional material; Optical bio-sensors; SARS-CoV- 2 (COVID-19); Two-dimensional materials; Viral disease; Virus detection, Coronavirus; COVID-19
Department/Centre: Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited: 22 Jan 2023 06:50
Last Modified: 22 Jan 2023 06:50
URI: https://eprints.iisc.ac.in/id/eprint/79228

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