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Ligand Exchange on MoS2Nanosheets: Applications in Array-Based Sensing and Drug Delivery

Behera, P and Karunakaran, S and Sahoo, J and Bhatt, P and Rana, S and De, M (2022) Ligand Exchange on MoS2Nanosheets: Applications in Array-Based Sensing and Drug Delivery. In: ACS Nano .

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Official URL: https://doi.org/10.1021/acsnano.2c06994


Two-dimensional MoS2 nanosheets (2D-MoS2) have been widely used in many biological applications due to their distinctive physicochemical properties. Further, the development of surface modification using thiolated ligands allows us to use them for many specific applications. But the effect of possible ligand exchange on 2D-MoS2 has never been explored, which can play an important role in diverse biological applications. In this study, we have observed the ligand-exchange phenomenon on 2D-MoS2 in the presence of different thiolated ligands. The initial study proceeded with boron-dipyrromethene (BODIPY) functionalized MoS2 with different concentrations of glutathione (GSH), which is the most abundant thiol species in the cytoplasm of various cancer cells. It was found that in the presence of GSH the fluorescence of BODIPY can be regenerated, which is time and concentration dependent. We have also examined this phenomenon with different thiol ligands and transition-metal dichalcogenides (TMDs). We observed a variable rate of ligand exchange in different solvents, surface functionality, and receptor environments that helped us to construct sensor arrays. Interestingly, a ligand-exchange process was not observed in the presence of dithiols. Further, this concept was applied to a cancerous cell line for in vitro delivery. We found that BODIPY-functionalized 2D-MoS2 undergoes thiol exchange by intracellular GSH and subsequently enhanced the fluorescence in the cytoplasm of cancer cells. This strategy can be applied to the development of 2D-TMD-based materials for various biological applications related to ligand exchange. © 2022 American Chemical Society.

Item Type: Journal Article
Publication: ACS Nano
Publisher: American Chemical Society
Additional Information: The copyright for this article belongs to American Chemical Society.
Keywords: Cancer cells; Cell culture; Cells; Controlled drug delivery; Diseases; Fluorescence; Ligands; Molybdenum compounds; Physicochemical properties; Targeted drug delivery, Array-based thiol sensor; Biological applications; Boron dipyrromethene; Dichalcogenides; Functionalized; Ligand exchanges; Surface Functionalization; Thiol ligand exchange; Thiols sensors; Transition-metal dichalcogenides, Transition metals
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Division of Chemical Sciences > Organic Chemistry
Date Deposited: 19 Jan 2023 10:14
Last Modified: 19 Jan 2023 10:14
URI: https://eprints.iisc.ac.in/id/eprint/79215

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