Kaddoumi, A and Denney, Jr and Deshpande, G and Robinson, JL and Beyers, RJ and Redden, DT and Praticò, D and Kyriakides, TC and Lu, B and Kirby, AN and Beck, DT and Merner, ND (2022) Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial. In: Nutrients, 14 (23).
|
PDF
nut_14-23_2022.pdf - Published Version Download (1MB) | Preview |
Abstract
Mild cognitive impairment (MCI) and early Alzheimer’s disease (AD) are characterized by blood–brain barrier (BBB) breakdown leading to abnormal BBB permeability ahead of brain atrophy or dementia. Previous findings in AD mouse models have reported the beneficial effect of extra-virgin olive oil (EVOO) against AD, which improved BBB and memory functions and reduced brain amyloid-β (Aβ) and related pathology. This work aimed to translate these preclinical findings to humans in individuals with MCI. We examined the effect of daily consumption of refined olive oil (ROO) and EVOO for 6 months in MCI subjects on BBB permeability (assessed by contrast-enhanced MRI), and brain function (assessed using functional-MRI) as the primary outcomes. Cognitive function and AD blood biomarkers were also assessed as the secondary outcomes. Twenty-six participants with MCI were randomized with 25 participants completed the study. EVOO significantly improved clinical dementia rating (CDR) and behavioral scores. EVOO also reduced BBB permeability and enhanced functional connectivity. While ROO consumption did not alter BBB permeability or brain connectivity, it improved CDR scores and increased functional brain activation to a memory task in cortical regions involved in perception and cognition. Moreover, EVOO and ROO significantly reduced blood Aβ42/Aβ40 and p-tau/t-tau ratios, suggesting that both altered the processing and clearance of Aβ. In conclusion, EVOO and ROO improved CDR and behavioral scores; only EVOO enhanced brain connectivity and reduced BBB permeability, suggesting EVOO biophenols contributed to such an effect. This proof-of-concept study justifies further clinical trials to assess olive oil’s protective effects against AD and its potential role in preventing MCI conversion to AD and related dementias. © 2022 by the authors.
| Item Type: | Journal Article |
|---|---|
| Publication: | Nutrients |
| Publisher: | MDPI |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | Alzheimer’s disease; amyloid beta peptides; blood–brain barrier; cognitive function; contrast-enhanced MRI; extra-virgin olive oil; functional MRI; mild cognitive impairment; refined olive oil; tau |
| Department/Centre: | Autonomous Societies / Centres > Centre for Brain Research |
| Date Deposited: | 17 Jan 2023 10:07 |
| Last Modified: | 17 Jan 2023 10:07 |
| URI: | https://eprints.iisc.ac.in/id/eprint/79193 |
Actions (login required)
 |
View Item |
