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Emerging trends in humidity-responsive 4D bioprinting

Mandal, A and Chatterjee, K (2022) Emerging trends in humidity-responsive 4D bioprinting. In: Chemical Engineering Journal .

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Official URL: https://doi.org/10.1016/j.cej.2022.140550


4D bioprinting is poised to usher in a new era of tissue engineering, where 3D printed, cell-laden scaffolds can be stimulated to enable functional responses or undergo complex morphological transformations. However, the over-reliance on smart hydrogels and the scarcity of cytocompatible stimuli remain significant bottlenecks in this field. To address these critical bottlenecks in this field, water has been employed as a stimulus to drive actuation mechanisms by harnessing the innate swelling behavior of hydrogels. This review presents a comprehensive overview of humidity-responsive 4D bioprinting, highlighting its unparalleled advantages as well as its ease of adoption and implementation. The state-of-the-art advances are critically examined, laying special emphasis on material composition, printing technology, design strategy, mechanism of deformation as well as potential areas of application. The fundamental aspects of mathematical modeling are briefly touched upon. Finally, the current limitations and the future directions that can propel further advancements and clinical translation are discussed.

Item Type: Journal Article
Publication: Chemical Engineering Journal
Publisher: Elsevier B.V.
Additional Information: The copyright for this article belongs to Elsevier B.V.
Keywords: Cell engineering; Hydrogels; Scaffolds (biology); Tissue, 3d bioprinting; 4d bioprinting; Bioprinting; Emerging trends; Functional response; Morphological transformations; Over reliance; Stimuli-responsive; Tissues engineerings, 3D printers
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 14 Jan 2023 06:51
Last Modified: 14 Jan 2023 06:51
URI: https://eprints.iisc.ac.in/id/eprint/79147

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