Pal, UM and Gk, AV and Gogoi, G and Rila, S and Shroff, S and Am, G and Borah, P and Varma, M and Kurpad, V and Baruah, D and Vaidya, JS and Pandya, HJ (2020) Towards a Portable Platform Integrated with Multispectral Noncontact Probes for Delineating Normal and Breast Cancer Tissue Based on Near-Infrared Spectroscopy. In: IEEE Transactions on Biomedical Circuits and Systems, 14 (4). pp. 879-888.
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Abstract
Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen. This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope. This process is labor-intensive and requires highly skilled doctors (pathologists). In this paper, we report a novel tool based on near-infrared spectroscopy (Spectral-IRDx) which is a portable, non-contact, and cost-effective system and could provide a rapid and accurate diagnosis of cancer. The Spectral-IRDx tool performs absorption spectroscopy at near-infrared (NIR) wavelengths of 850, 935, and 1060 nm. We measure normalized detected voltage (Vdn) with the tool in 10 deparaffinized breast biopsy tissue samples, 5 of which were cancer (C) and 5 were normal (N) tissues. The difference in Vdn at 935 nm and 1060 nm between cancer and normal tissues is statistically significant with p-values of 0.0038 and 0.0022 respectively. Absorption contrast factor (N/C) of 1.303, 1.551, and 1.45 are observed for 850, 935, and 1060 nm respectively. The volume fraction contrast (N/C) of lipids and collagens are reported as 1.28 and 1.10 respectively. Higher absorption contrast factor (N/C) and volume fraction contrast (N/C) signifies higher concentration of lipids in normal tissues as compared to cancerous tissues, a basis for delineation. These preliminary results support the envisioned concept for noninvasive and noncarcinogenic NIR-based breast cancer diagnostic platform, which will be tested using a larger number of samples. © 2007-2012 IEEE.
| Item Type: | Journal Article |
|---|---|
| Publication: | IEEE Transactions on Biomedical Circuits and Systems |
| Publisher: | Institute of Electrical and Electronics Engineers Inc. |
| Additional Information: | The copyright for this article belongs to the Author(S). |
| Keywords: | Absorption spectroscopy; Biopsy; Cost effectiveness; Diseases; Histology; Infrared devices; Lipids; Near infrared spectroscopy; Volume fraction, Breast cancer diagnostics; Cancerous tissues; Cost effective systems; Detected voltages; Hematoxylin eosin; Near-infrared wavelength; Non-contact probe; Number of samples, Tissue, collagen; lipid, biopsy; breast; breast tumor; chemistry; cytochemistry; devices; equipment design; female; human; near infrared spectroscopy; pathology; procedures, Biopsy; Breast; Breast Neoplasms; Collagen; Equipment Design; Female; Histocytochemistry; Humans; Lipids; Spectroscopy, Near-Infrared |
| Department/Centre: | Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology) Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering |
| Date Deposited: | 13 Jan 2023 06:50 |
| Last Modified: | 13 Jan 2023 06:50 |
| URI: | https://eprints.iisc.ac.in/id/eprint/79112 |
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