Sarkar, B and Jayaraman, N (2020) Glycoconjugations of Biomolecules by Chemical Methods. In: Frontiers in Chemistry, 8 .
|
PDF
fro_che_8_2020.pdf - Published Version Download (7MB) | Preview |
Abstract
Bioconjugations under benign aqueous conditions have the most promise to covalently link carbohydrates onto chosen molecular and macromolecular scaffolds. Chemical methodologies relying on C-C and C-heteroatom bond formations are the methods of choice, coupled with the reaction conditions being under aqueous milieu. A number of methods, including metal-mediated, as well as metal-free azide-alkyne cyclo-addition, photocatalyzed thiol-ene reaction, amidation, reductive amination, disulfide bond formation, conjugate addition, nucleophilic addition to vinyl sulfones and vinyl sulfoxides, native chemical ligation, Staudinger ligation, olefin metathesis, and Suzuki-Miyaura cross coupling reactions have been developed, in efforts to conduct glycoconjugation of chosen molecular and biomolecular structures. Within these, many methods require pre-functionalization of the scaffolds, whereas methods that do not require such pre-functionalization continue to be few and far between. The compilation covers synthetic methodology development for carbohydrate conjugation onto biomolecular and biomacromolecular scaffolds. The importance of such glycoconjugations on the functional properties is also covered. © Copyright © 2020 Sarkar and Jayaraman.
| Item Type: | Journal Article |
|---|---|
| Publication: | Frontiers in Chemistry |
| Publisher: | Frontiers Media S.A. |
| Additional Information: | The copyright for this article belongs to the Author(s). |
| Keywords: | biomolecules; carbohydrates; conjugations; glycoconjugations; lipids; nucleic acids; peptides; proteins |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 10 Jan 2023 09:36 |
| Last Modified: | 10 Jan 2023 09:36 |
| URI: | https://eprints.iisc.ac.in/id/eprint/79016 |
Actions (login required)
 |
View Item |
