RAD51 paralogs: Expanding roles in replication stress responses and repair

Bhattacharya, D and Sahoo, S and Nagraj, T and Dixit, S and Dwivedi, HK and Nagaraju, G (2022) RAD51 paralogs: Expanding roles in replication stress responses and repair. In: Current Opinion in Pharmacology, 67 .

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Abstract

Mammalian RAD51 paralogs are essential for cell survival and are critical for RAD51-mediated repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). However, the molecular mechanism by which RAD51 paralogs participate in HR is largely unclear. Germline mutations in RAD51 paralogs are associated with breast and ovarian cancers and Fanconi anemia-like disorder, underscoring the crucial roles of RAD51 paralogs in genome maintenance and tumor suppression. Despite their discovery over three decades ago, the essential functions of RAD51 paralogs in cell survival and genome stability remain obscure. Recent studies unravel DSB repair independent functions of RAD51 paralogs in replication stress responses. Here, we highlight the recent findings that uncovered the novel functions of RAD51 paralogs in replication fork progression, its stability, and restart and discuss RAD51 paralogs as a potential therapeutic target for cancer treatment. © 2022 Elsevier Ltd

Item Type:	Journal Article
Publication:	Current Opinion in Pharmacology
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	30 Dec 2022 08:16
Last Modified:	30 Dec 2022 08:16
URI:	https://eprints.iisc.ac.in/id/eprint/78631

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