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Utility of ZrO2–Al2O3 in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones

Narasimhamurthy, KH and Girish, YR and Thimmaraju, N and Rangappa, KS (2019) Utility of ZrO2–Al2O3 in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones. In: Chemical Data Collections, 21 .

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Official URL: https://doi.org/10.1016/j.cdc.2019.100230


In this paper, we report the synthesis of a nano acid catalyst ZrO2–Al2O3 by using urea as a fuel and the evaluation of its catalytic efficiency in the synthesis of a series of novel substituted dihydroquinazolinones. The catalyst was found to be a highly effective solid acid catalyst, and it exhibited significant catalytic activity in converting substituted 2-aminobenzamides into corresponding 2, 3-dihydroquinazolin-4(1H)-ones under mild conditions. The optimized synthetic method is facile, rapid and efficient and may emerge as one of the best methodologies for accessing pharmaceutically useful dihydroquinazolines.

Item Type: Journal Article
Publication: Chemical Data Collections
Publisher: Elsevier B.V.
Additional Information: The copyright for this article belongs to Elsevier B.V.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 27 Dec 2022 05:23
Last Modified: 27 Dec 2022 05:23
URI: https://eprints.iisc.ac.in/id/eprint/78550

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